Medical Weight Loss with GLP-1 Medications in Southlake, TX
Semaglutide, Tirzepatide, and Retatrutide in Southlake, TX. Your starting dose is set at consultation and adjusted as you respond.
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Three GLP-1 medications
Each medication acts on a different combination of hormone pathways. Dr. Mikki confirms your candidacy, sets your starting dose, and adjusts it at your follow-up visits.
Semaglutide
A once-weekly injection that acts on the GLP-1 hormone pathway. It reduces appetite and slows how fast your stomach empties, so you feel full sooner and stay full for longer.
Tirzepatide
A once-weekly injection that acts on two hormone pathways instead of one, GLP-1 and GIP. It reduces appetite and supports blood-sugar control at the same time.
Retatrutide
An injection that acts on three hormone pathways, GLP-1, GIP, and glucagon. It is an emerging medication, so Dr. Mikki decides candidacy for it at your consultation.
How GLP-1 and GIP medications work
All three medications act on hormone pathways your body already uses to regulate appetite and blood sugar. Semaglutide works on one receptor and tirzepatide on two.
GLP-1 compared with the GLP-1 and GIP combination
This is the comparison patients arrive with. Both are once-weekly injections and both are FDA-approved for weight management under one brand name and for type 2 diabetes under another.
| Axis of comparison | GLP-1 (semaglutide) | GLP-1 and GIP (tirzepatide) |
|---|---|---|
| Mechanism of action | GLP-1:A GLP-1 receptor agonist. It enhances insulin secretion, reduces appetite, and slows gastric emptying. | GLP-1 and GIP:A dual GLP-1 and GIP receptor agonist, so it acts on a second hormone receptor as well. |
| FDA approvals | GLP-1:Ozempic for type 2 diabetes and Wegovy for weight loss. | GLP-1 and GIP:Mounjaro for type 2 diabetes and Zepbound for weight management. |
| Dosing | GLP-1:A once-weekly subcutaneous injection. | GLP-1 and GIP:A once-weekly subcutaneous injection. |
| Weight change in clinical trials | GLP-1:Around 15% of body weight with Wegovy. | GLP-1 and GIP:Up to 20-25% of body weight. |
| Blood sugar control | GLP-1:Improves insulin sensitivity. | GLP-1 and GIP:Improves insulin sensitivity, and has shown slightly greater HbA1c reductions. |
| Side effects | GLP-1:Gastrointestinal side effects, usually mild and temporary. | GLP-1 and GIP:Similar gastrointestinal side effects, usually mild and temporary. |
| Which one you are prescribed | GLP-1:A consultation decision, taken against your history and any other conditions. | GLP-1 and GIP:A consultation decision, taken against your history and any other conditions. |
About those percentages
Both figures are averages reported in clinical trials, not a forecast for any one patient. What you can expect is a conversation at your consultation, not a number quoted from a website. Results vary from patient to patient.
Other benefits of GLP-1 and GIP injections
Appetite and blood sugar are what these medications act on. What patients tend to ask about next is everything around that: how it is supervised, what it asks of your week, and how it sits with the rest of your health.
Weight loss that is medically supervised
The weight change is the headline benefit, and Dr. Mikki writes and monitors the prescription in person. These are FDA-approved medications used inside a supervised program, not an online form.
Support for your metabolic health
The same hormone pathways that govern appetite also govern blood sugar, which is why these molecules are approved for type 2 diabetes as well as for weight management.
Lower risk from weight-related conditions
Carrying less weight is linked to a lower risk of the conditions that track with obesity, including the cardiovascular risks Dr. Mikki reviews against your own history.
A non-surgical option
This is a weekly subcutaneous injection. There is no procedure, no anesthetic and no recovery period to plan around.
Convenient to take
You give the injection yourself once a week, and you are shown how at your first visit. It fits around your week rather than the other way around.
Built around your own history
Your plan is tailored to your medical history, your other prescriptions and your lifestyle, and it can run alongside an HRT or peptide plan managed in the same clinic.
What this list is and is not
These are the benefits Dr. Mikki and the published labeling describe for this class of medication, not a promise about your own result. Which benefits apply to you depends on your history, and results vary from patient to patient.
What your first weight-loss visit looks like
Consultation and history
Dr. Mikki reviews your health history and every medication you already take, which is the part a form on a website cannot do.
Candidacy is confirmed
She checks your BMI and any weight-related conditions, and screens for the reasons a GLP-1 would not be appropriate for you.
Prescription and starting dose
She writes the prescription and sets your starting dose herself, then shows you how the weekly injection is given.
Follow-up and adjustment
Doses are titrated upward over several weeks and adjusted at each follow-up based on how you respond. Most people begin to notice change within a few weeks, with full effects typically seen after three to six months of consistent use. Results vary from patient to patient.
What your weight-loss plan includes
Your plan starts with a consultation. Dr. Mikki confirms you are a candidate, writes the prescription, and changes your dose at each follow-up. A mail-order program works the other way around: you fill in a form online and the medication is shipped to you.
| Feature | Medrein | Mail-Order GLP-1 |
|---|---|---|
| Candidacy confirmed at an in-person consultation | Included | Not included |
| Dose changed at follow-up based on your response | Included | Varies |
| Runs alongside your Peptide Therapy or HRT plan | Included | Not included |
| Timelines set at the first visit | Included | Varies |
Who GLP-1 weight loss is for and what to expect
Candidacy is confirmed by Dr. Mikki, not by a questionnaire, and it can be co-managed with your hormone plan or an NAD add-on in the same visit.
Who may be a candidate
- Your BMI is over 31.
- Your BMI is over 27 and you have a weight-related medical condition.
- You have diabetes or another medical condition. These programs are used by patients who do, and Dr. Mikki reviews your other prescriptions alongside this one.
- You are willing to pair the medication with lifestyle changes. Results hold longest where the habits introduced during the program continue afterward.
- You want the prescription written and monitored in person rather than issued off an online form.
Possible side effects
- Nausea or vomiting.
- Diarrhea or constipation.
- Abdominal pain.
- A skin rash at the injection site.
- These are usually mild and temporary, and worth telling Dr. Mikki about at your follow-up rather than pushing through.
Raise these before you start
Tell Dr. Mikki about your medical history and every medication you are taking, including anything you take for diabetes. Ask what it will cost — that varies with your insurance coverage and your pharmacy. And expect a gradual change rather than a fast one: results vary from patient to patient.
What patients say
These reflect common patient sentiment rather than verbatim quotes, and individual results vary.
Dr. Mikki went through my history, started me on a low dose, and explained exactly why she was raising it each time. When a side effect showed up she adjusted the plan instead of telling me to push through. Results may vary, but I always knew what I was taking and why.
No promises about how fast it would work. Just a dose that changed as my body did.
Frequently asked questions
Which medications does Medrein use for medical weight loss?
Semaglutide, Tirzepatide, and Retatrutide, with NAD available as an add-on. Dr. Mikki decides which one fits your history at your consultation.
What happens at my first visit?
Dr. Mikki reviews your health history, confirms you are a candidate, writes the prescription, and sets your starting dose. She adjusts that dose at each follow-up based on how you respond.
Who is a candidate for GLP-1 medical weight loss?
It depends on your BMI, your health history, and any weight-related conditions. Dr. Mikki confirms candidacy and screens for contraindications at your consultation.
How soon will I see results?
GLP-1 doses are titrated upward over several weeks, so the change is gradual. Results vary from patient to patient.
Can I add NAD or other treatments to my weight-loss plan?
Yes. NAD is available as an add-on, and your plan can run alongside Peptide Therapy or Hormone Replacement Therapy in the same visit.
How do I get started?
Book a consultation online or call (214) 702-5225. Dr. Mikki reviews your history and talks through your medication options at that visit.
Are your weight-loss programs safe if I have diabetes or another condition?
Yes. These programs are used by patients with diabetes and with other conditions. Losing extra weight may ease your symptoms and lower the dose of insulin you need, so Dr. Mikki reviews your other prescriptions alongside this one.
How much do GLP-1 medications cost?
The cost varies with your insurance coverage and the pharmacy you use. Options for bringing it down are discussed at your consultation.
How long will I need to stay on treatment?
The duration depends on your own condition and what you need. Results can be long-term if you keep up the lifestyle habits introduced during the program.
Find out which medication fits you
Dr. Mikki reviews your history, confirms candidacy, and outlines your GLP-1 options before anything is prescribed.
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