NAD+ IV and Injection Therapy in Southlake, TX
NAD+ is a coenzyme with an important role in cellular energy metabolism. It is given as an IV infusion or as a subcutaneous injection, at a pace set to your tolerance.
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NAD+ supports cellular energy metabolism
NAD+ is a coenzyme, not a peptide. It plays an important role in cellular energy metabolism and in DNA-related processes, and levels decline with age. Medrein lists it next to the energy peptides because patients arrive asking about all of them together, not because NAD+ is one, and offers it as an add-on within medical weight loss plans.
What NAD+ therapy involves
What NAD+ does in the cell, and why levels fall
Fatigue and brain fog are the two things patients most often mention when they ask Dr. Mikki about NAD+. What follows is what the coenzyme does in the body, so the therapy can be weighed on that rather than on the promise.
A coenzyme in every living cell
NAD+ is nicotinamide adenine dinucleotide, a coenzyme found in all living cells. Energy production and DNA repair both depend on it, and so do hundreds of other metabolic processes, which is why Dr. Mikki treats it as basic cell biology rather than as a supplement.
Its part in mitochondrial energy production
NAD+ participates in mitochondrial ATP synthesis, the step at which a cell converts nutrients into usable energy. It is also involved in sirtuin activity, in DNA repair and in circadian regulation.
Levels decline as you age
NAD+ levels fall with age, by roughly 50% between ages 40 and 60. That decline is why NAD+ is studied in relation to fatigue and metabolic change, though a causal link to any one person’s symptoms has not been established.
It replenishes rather than stimulates
NAD+ therapy aims to replenish those levels. Whether replenishing them changes metabolism, appetite or weight in patients has not been established, so it is offered as a possible support inside a wider plan rather than as a treatment with a proven effect. NAD+ is not a stimulant, and results may vary.
NAD+ IV infusion or subcutaneous injection
Medrein offers both. They deliver the same coenzyme, but they are not interchangeable: the routes differ in how the dose reaches you, how long the appointment runs and how it feels. Dr. Mikki decides between them with you rather than leaving it to preference alone.
NAD+ IV infusion
The coenzyme goes straight into the bloodstream through a drip, given at the clinic with a clinician present. Infusions are run deliberately slowly, because NAD+ delivered too quickly can feel uncomfortable, and that pacing is the whole reason this belongs in a medical setting rather than a walk-in bar.
- Given in-clinic under medical supervision, never unattended.
- The rate is set to your tolerance and slowed the moment you need it.
- A session runs over roughly two to four hours, so plan the visit rather than squeezing it in.
NAD+ subcutaneous injection
The same coenzyme, given as a small injection under the skin instead of through a drip. It is the shorter appointment, and it is the route Dr. Mikki reaches for when sitting through an infusion does not suit your schedule or your tolerance.
- A much shorter visit than an infusion.
- The same molecule by a different route, which changes how it is absorbed and how the visit feels. It is a clinical choice rather than a preference.
- The route is chosen with you at consultation and can change as your plan does.
Why patients ask about NAD+ therapy
These are the reasons patients raise NAD+ at consultation, in Dr. Mikki's own terms. They are not established effects of the therapy, and whether it helps with any of them is a question to work through against your own history.
A medical infusion, paced with care
NAD+ delivered too quickly can feel uncomfortable, so the drip is slowed to keep you at ease. That pacing is why it is administered under physician supervision rather than at a walk-in bar. Patients weighing signaling peptides for energy often ask about MOTS-C at the same visit.
| Feature | NAD+ (Medrein) | Walk-In Vitamin Drip | No Treatment |
|---|---|---|---|
| Delivered under physician supervision | Included | Varies | Not included |
| Infusion paced to your tolerance | Included | Varies | Not included |
| IV or subcutaneous route selected for you | Included | Not included | Not included |
| Can be built into a weight-loss plan | Included | Not included | Not included |
What a NAD+ session looks like
Dosing is Dr. Mikki's call at consultation, so you will not find a number on this page. What you will find is the sequence and the honest length of the appointment.
Consultation and plan
Dr. Mikki reviews your goals and overall health and builds a personalized plan. How many treatments you need varies with your goals and your health, so the number is settled with you rather than fixed before you arrive.
Route and pacing chosen
You and Dr. Mikki settle on IV infusion or subcutaneous injection. If it is an infusion, the rate is set to your tolerance from the first session and slowed whenever it needs to be.
The session itself
An infusion is given at the clinic with a clinician present, and runs over roughly two to four hours, so bring something to do. An injection is a far shorter visit for the same molecule.
Follow-up and adjustment
Dr. Mikki follows how you tolerate the therapy and adjusts the route, the pacing or the schedule. Early plans often run one or two sessions a week before spacing out, and yours is set at consultation rather than off a template.
When patients notice a change
Hours to days
Some people describe an energy change within hours to days of a session. Many describe nothing, and individual results vary.
Four to eight weeks
Her own guidance describes the fullest reported benefit at around four to eight weeks of a course rather than after any single visit. If nothing has changed for you by then, raise it with Dr. Mikki rather than carrying on in the expectation that it will.
Beyond the first course
How long you continue depends on your goals. Her guidance describes short courses of four to eight weeks, longer courses of twelve to sixteen weeks, and ongoing maintenance, and the choice is reviewed with Dr. Mikki rather than fixed at the start.
NAD+ safety and how an infusion feels
Why NAD+ therapy is considered safe here
- NAD+ therapy is generally safe and well tolerated when properly prescribed and monitored.
- Infusions are administered under medical supervision, with the drip slowed the moment you need it. That pacing is the point of doing this in a clinic.
- Prescribed and monitored by Dr. Haritha Mikkilineni, MD, a board-certified physician with 15+ years in emergency medicine behind her.
- Route, pacing and schedule are set to you at consultation and adjusted at every follow-up.
- Candidacy is confirmed against your goals and your overall health before a first session is booked.
What to weigh honestly
- Mild flushing, nausea or headache, which usually subside quickly.
- Discomfort if an infusion runs too fast, which is exactly why the drip is deliberately slowed.
- An infusion is a real time commitment, not a ten-minute stop on the way to work.
- Not recommended during pregnancy or while breastfeeding.
- NAD+ therapy for energy, weight or longevity is not an FDA-approved use. It is given off-label under physician supervision, and no page here will suggest otherwise.
Who NAD+ therapy is for
Dr. Mikki confirms candidacy against your goals and your overall health, and will point you to another part of the peptide therapy program, or to a weight loss plan on its own, when one of those fits you better.
A good fit
- You are already in, or considering, a physician-managed weight-loss or wellness plan and are asking what might support it.
- You want a whole-person approach rather than one that works on appetite alone.
- You want to work on your overall health and wellbeing rather than a single number.
- You are committed to the diet and exercise changes any such plan depends on.
- You have had fatigue or brain fog properly worked up, so the common causes have been looked for rather than assumed.
Not the right treatment
- Anyone wanting a stimulant-style lift. NAD+ replenishes a coenzyme; it does not stimulate you.
- Pregnancy or breastfeeding.
- Anyone expecting weight loss from NAD+ itself. It is not a weight-loss treatment and it is not a substitute for diet, exercise or a prescribed plan.
- Anyone who cannot commit to a course of visits and the follow-up that goes with it.
Before you book, three things worth knowing
NAD+ therapy for energy, weight or longevity is given off-label under physician supervision; it is not an FDA-approved use. Cost depends on the route and the number of treatments in your plan, so it is quoted at consultation rather than published as a range that would not apply to you. And it is planned as a course rather than a single visit, so agree with Dr. Mikki up front what you would expect to see and when you would both stop. Results may vary.
Why patients choose NAD+ at Medrein
These reflect common patient sentiment rather than verbatim quotes, and individual results vary.
I had read about NAD+ drips and expected a quick pick-me-up. Dr. Mikki was straight with me that it is a coenzyme, not a stimulant, and that the infusion has to be slowed down to stay comfortable. She folded it into my weight-loss plan and explained why. Results may vary, but I never felt sold to. I felt informed.
She slowed the drip when I needed it and never rushed the appointment. That mattered.
Frequently asked questions
What is NAD+, and is it a peptide?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme, not a peptide. It has an important role in converting nutrients into usable energy and in DNA repair processes. It is listed with the energy and mitochondrial peptides at Medrein because patients ask about them together, but NAD+ is a distinct type of molecule.
How is NAD+ delivered, IV or injection?
NAD+ can be given by IV infusion or by subcutaneous injection. Dr. Mikki selects the route based on your goals and tolerance. Infusions are paced deliberately, because NAD+ delivered too quickly can feel uncomfortable, so the drip is slowed to keep you comfortable.
What do patients use NAD+ for?
Energy, mental clarity and recovery are the reasons patients ask about NAD+. Levels decline with age, and the therapy aims to replenish them, but effects on any of those three are not established. It is not a stimulant, and results may vary.
Can NAD+ be combined with weight-loss treatment?
Yes. NAD+ is often used as an add-on within a physician-managed medical weight-loss plan alongside a GLP-1 medication. Dr. Mikki decides whether it adds value to your program and confirms candidacy at consultation.
How is NAD+ different from MOTS-C or SS-31?
All three are involved in cellular energy and act differently. NAD+ is a coenzyme used directly in energy production. MOTS-C is a signaling peptide that engages metabolic pathways. SS-31 targets the inner mitochondrial membrane. Dr. Mikki explains which fits your goals at consultation.
Is NAD+ therapy safe, and who supervises it?
NAD+ therapy is prescribed and monitored by Dr. Haritha Mikkilineni, MD, a board-certified physician. She confirms candidacy, sets the route and pacing, and follows up on how you tolerate it. Infusions are administered under medical supervision.
How many NAD+ treatments will I need?
The number varies with your goals and your overall health, so it is decided with you at consultation rather than sold as a fixed package. Early plans often run one or two sessions a week before spacing out, and Dr. Mikki adjusts the schedule against how you respond. Courses run roughly four to eight weeks, longer, or as ongoing maintenance depending on what you are after.
What are the side effects of NAD+ therapy?
NAD+ therapy is generally safe and well tolerated. Some people experience mild side effects such as flushing, nausea or headache, which usually subside quickly. An infusion delivered too quickly can feel uncomfortable, which is why the drip is paced deliberately and slowed whenever you need it. NAD+ therapy is not recommended during pregnancy or breastfeeding.
How much does NAD+ therapy cost?
Cost depends on the route and the number of treatments in your plan, so Medrein quotes it transparently at consultation instead of publishing a range that would not apply to you. Financing options are discussed at the same visit, once Dr. Mikki knows what your plan actually involves.
Is NAD+ therapy right for you?
Dr. Mikki reviews your energy goals, confirms candidacy, and sets the route and pacing that keep the infusion comfortable.
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